2003 FEB 4 - (NewsRx.com & NewsRx.net) -- According to a study from Spain, "epidermal growth factor receptor (EGFR) expression is observed in 50%-70% of colorectal carcinomas and is associated with poor prognosis. The aim of this study was to determine the EGFR expression rate in locally advanced rectal cancer and to analyze whether EGFR expression predicts tumor response to preoperative radiotherapy."
Between December 1997 and October 2000, 45 patients were given "preoperative pelvic radiotherapy and, in 21 patients, 2 courses of 5-fluorouracil leucovorin. Surgical resection was performed 4 to 8 weeks later. Immunohistochemistry for EGFR was determined at the …
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